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Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 [ Mus musculus (house mouse) ]

Gene ID: 21941, updated on 2-Nov-2024

Summary

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Official Symbol
Tnfrsf8provided by MGI
Official Full Name
tumor necrosis factor receptor superfamily, member 8provided by MGI
Primary source
MGI:MGI:99908
See related
Ensembl:ENSMUSG00000028602 AllianceGenome:MGI:99908
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ki; Cd30; Ki-1; D1S166E
Summary
Predicted to enable protease binding activity. Predicted to be involved in positive regulation of TRAIL production; positive regulation of apoptotic process; and positive regulation of tumor necrosis factor production. Predicted to be located in nucleoplasm and plasma membrane. Is expressed in several structures, including adrenal gland; brain; intestine; reproductive system; and thymus. Orthologous to human TNFRSF8 (TNF receptor superfamily member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in thymus adult (RPKM 4.6), testis adult (RPKM 0.6) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Tnfrsf8 in Genome Data Viewer
Location:
4 E1; 4 78.17 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (144993702..145041734, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (145267132..145315164, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor receptor superfamily, member 1b Neighboring gene STARR-positive B cell enhancer ABC_E11265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:144832691-144832800 Neighboring gene STARR-positive B cell enhancer ABC_E8008 Neighboring gene predicted gene, 36233 Neighboring gene STARR-seq mESC enhancer starr_12014 Neighboring gene STARR-seq mESC enhancer starr_12016 Neighboring gene STARR-positive B cell enhancer mm9_chr4:144885570-144885871 Neighboring gene STARR-positive B cell enhancer ABC_E1663 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:144909212-144909413 Neighboring gene STARR-seq mESC enhancer starr_12020 Neighboring gene STARR-positive B cell enhancer ABC_E9608 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:144957328-144957437 Neighboring gene STARR-seq mESC enhancer starr_12022 Neighboring gene STARR-positive B cell enhancer mm9_chr4:144995732-144996033 Neighboring gene high mobility group box 2 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr4:144997421-144997722 Neighboring gene STARR-seq mESC enhancer starr_12024 Neighboring gene predicted gene, 42346 Neighboring gene STARR-seq mESC enhancer starr_12025 Neighboring gene STARR-positive B cell enhancer ABC_E9609 Neighboring gene STARR-positive B cell enhancer ABC_E2132 Neighboring gene STARR-positive B cell enhancer mm9_chr4:145039173-145039474 Neighboring gene STARR-positive B cell enhancer mm9_chr4:145043961-145044261

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NK cells protect secondary lymphoid tissue from cytomegalovirus via a CD30-dependent mechanism. Bekiaris V, et al. Eur J Immunol, 2009 Oct. PMID 19731363
  2. Expression of the costimulatory receptor CD30 is regulated by both CD28 and cytokines. Gilfillan MC, et al. J Immunol, 1998 Mar 1. PMID 9498756
  3. Inhibition of type 1 cytokine-mediated inflammation by a soluble CD30 homologue encoded by ectromelia (mousepox) virus. Saraiva M, et al. J Exp Med, 2002 Sep 16. PMID 12235215, Free PMC Article
  4. TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 mitogen-activated protein kinase-dependent mechanism. Harlin H, et al. J Immunol, 2002 Sep 1. PMID 12193714
  5. Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. Amakawa R, et al. Cell, 1996 Feb 23. PMID 8598042

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD30 plays a role in T-dependent immune response and T cell proliferation.
    Title: CD30 plays a role in T-dependent immune response and T cell proliferation.
  2. CD30 co-stimulation drives differentiation of protective T cells during Mycobacterium tuberculosis infection.
    Title: CD30 co-stimulation drives differentiation of protective T cells during Mycobacterium tuberculosis infection.
  3. CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.
    Title: CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.
  4. Blockade of tumor necrosis factor superfamily members CD30 and OX40 abrogates disease activity in murine immune-mediated glomerulonephritis.
    Title: Blockade of tumor necrosis factor superfamily members CD30 and OX40 abrogates disease activity in murine immune-mediated glomerulonephritis.
  5. Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation.
    Title: Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation.
  6. CD30L/CD30 signaling regulates the formation of the tumor immune microenvironment and inhibits intestinal tumor development of colitis-associated colon cancer in mice.
    Title: CD30L/CD30 signaling regulates the formation of the tumor immune microenvironment and inhibits intestinal tumor development of colitis-associated colon cancer in mice.
  7. chronic CD30 signaling increases the risk of B-cell lymphomagenesis.
    Title: Chronic CD30 signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells.
  8. This study demonstrated the amelioration of MOG35-55 peptide-induced active EAE in CD30 KO mice. CD30 was expressed limitedly on CD4 T cells at the induction phase of experimental autoimmune encephalomyelitis.
    Title: Requirement of CD30 expression on CD4 T cells in the pathogenesis of experimental autoimmune encephalomyelitis.
  9. Data indicate that CD30L/CD30 axis plays a modulatory role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE).
    Title: CD30 ligand is a new therapeutic target for central nervous system autoimmunity.
  10. role in the maintenance and activation of IL-17A-producing gammadelta T cells
    Title: CD30L/CD30 is critical for maintenance of IL-17A-producing γδ T cells bearing Vγ6 in mucosa-associated tissues in mice.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of TRAIL production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 8
Names
CD30L receptor
lymphocyte activation antigen CD30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009401.3 → NP_033427.1  tumor necrosis factor receptor superfamily member 8 precursor

    See identical proteins and their annotated locations for NP_033427.1

    Status: VALIDATED

    Source sequence(s)
    AL627099
    Consensus CDS
    CCDS18915.1
    UniProtKB/Swiss-Prot
    A1L3C9, Q60846
    Related
    ENSMUSP00000030339.7, ENSMUST00000030339.13
    Conserved Domains (1) summary
    cd13409
    Location:3 → 127
    TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    144993702..145041734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163966.1 → XP_036019859.1  tumor necrosis factor receptor superfamily member 8 isoform X1

    Conserved Domains (2) summary
    PTZ00449
    Location:117 → 274
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd13409
    Location:6 → 112
    TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60846.1 GenPept UniProtKB/Swiss-Prot:Q60846

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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